April 17, 2014, 12:10 p.m. EDT
By Meena Krishnamsetty and Javier Hasse
Insiders are contrarian investors. They get greedy when others are 
fearful and they dump their holdings when investors are greedy. The 
research we conducted at Insider Monkey has shown that stocks bought by 
insiders tend to         outperform market indexes
. Although an insider purchase is a good signal, it shouldn't be the 
only factor you take into account when making decisions. Investors must 
look into other elements, like the company's fundamentals, valuation and
 institutional ownership in order to make better decisions. In this 
article we will look into five mid-cap companies with insider purchases 
and analyze other essentials to help you see if they stand as attractive
 long-term investment options. 
Biotechnology
First in our list is Alnylam Pharmaceuticals, Inc.                 
                    
                        ALNY
                            +0.24%
                    
                
. This $3.88 billion market cap biopharmaceutical company develops novel
 therapeutics based on RNA interference. On March 25,         Sanofi-Aventis
, a large Shareholder -which owns more than 10% of the company´s common 
stock, purchased 344 thousand shares of the company for $66.88 per 
share. After spending more than $23 million in Alnylam's stock, Sanofi 
holds (indirectly, via a wholly-owned subsidiary, Genzyme Corp.) more 
than 9.1 million shares of the biopharmaceutical. 
If we only analyze Alnylam's fundamentals, these purchases make no sense
 whatsoever: the company boasts negative margins and returns, while its 
stock´s valuation, at 80 times the company´s sales and 14.6 times its 
book value, seems a little too high. However, its long-term growth 
prospects and upside potential (a mean price target of $101 per share 
implies an upside potential of more than 68%) make of this company a 
much more appealing investment option. 
In addition, the purchase must be understood in the context of Sanofi's 
$20.1 billion acquisition of Genzyme, which took place in 2011. 
Alnylam's Patisiran, a therapy for a life-threatening illness that 
damages the nervous system, and the rights to three other drugs are only
 some of the benefits that Genzyme gets from Sanofi´s increasing 
participation in Alnylam. 
On top of insiders and analysts, several major hedge funds seem to feel bullish about this stock. For instance,         David Greenspan
´s Slate Path Capital and         Richard Gerson and Navroz D. Udwadia
´s Falcon Edge Capital have recently reported new positions in Alnylam, with 1 million shares each.
                                        
The other biotech company that witnessed high insider activity over March is Intrexon Corp                 
                    
                        XON
                            -2.49%
                    
                
, a $2.5 billion market cap synthetic biology company that designs, 
builds and regulates gene programs using its proprietary -and 
complementary- technologies. Over March, the company witnessed three 
insider purchases. 
On March 27, the company's CEO -for 8 years already,         Randal Kirk
, bought 243,001 shares of the company, for $25.72 per share. Through         several holdings
, Mr. Kirk owns more than 62.5 million shares of Intrexon's stock, which makes him a more-than-10% owner. In addition,         Ian Gregory Frost
, Senior Vice President at the company's Health Sector, started a 
position in the stock with 100,000, though three separate purchases made
 between Feb. 28th and March 4. Among the 100,000 shares, 61,500 shares 
were procured between March 3 and March 4, for prices ranging from 
$24.56 per share to $26.15 per share, inclusive. 
Once again, looking at Intrexon's fundamentals alone doesn't provide an 
explanation for this strong bet. The company displays negative margins 
and returns, and its valuation, at 42 times its sales looks pricey. 
However, its growth prospects and upside potential make of this company a
 much more interesting investment option. In addition, March 2014 was an
 important month for the company, since it acquired Merck               
  
                    
                        MRK
                            +0.70%
                    
                
's wholly owned subsidiary Sirna Therapeutics, Inc. 
Major hedge funds also seem to believe in this firm´s potential. Several prominent investors, including         Dan Loeb
 (Third Point) and         David Einhorn
 (Greenlight Capital) do not only hold large stakes in the company, but 
also, have increased their positions over the last reported quarter. 
Oil & Gas Midstream
In the oil and gas midstream industry, two mid-cap companies experienced
 insider activity over the past month. The first one is Plains GP 
Holdings LP                 
                    
                        PAGP
                            -2.81%
                    
                
, a $3.7 billion market cap firm that, through its general partner Plains All American Pipeline, L.P.                 
                    
                        PAA
                            +0.09%
                    
                
, is engaged in the transportation, storage, terminalling and marketing 
of crude oil and refined products. Plains GP IPOed last October and 
managed to raise $3 billion in its debut. 
On March 13th,         Victor Burk
, a Board Director, started a position in the company with 3,000 shares.
 He paid prices ranging from $27.08 per share to $27.09 per share. His 
holdings are valued at approximately $84,000. 
Same as in the previous cases, Plains GP Holdings' margins and returns 
stand quite below its industry's average values. In addition, its stock 
trades at sky-high valuations in relation to the firm´s earnings (256x 
P/E) and book-values (16.9x P/B). However insiders, analysts, and even 
hedge funds still seem to think this stock is worth it. UBS recently 
raised its price target for Plains GP to $32 per share, which implies an
 upside potential of roughly 11%. In addition, about 20 prominent 
investors have taken positions in it. For instance,         Alec Litowitz and Ross Laser
's Magnetar Capital recently added more than 3.5 million shares of this 
stock to its equity portfolio. This holding is worth more than $98 
million, accounting for approximately 2% of its total holdings. Other 
investment gurus with large stakes in the company that are worth 
mentioning are         Phill Gross, Robert Atchinson
,         Doug Silverman
,         Ken Griffin
,         D.E. Shaw
 and         Israel Englander
. 
The other oil and gas midstream company in our list is MPLX LP                 
                    
                        MPLX
                            +0.12%
                    
                
, a limited partnership recently formed by Marathon Petroleum 
Corporation (to own, operate, develop and acquire crude oil, refined 
product and other hydrocarbon-based product pipelines and other 
midstream assets), with a market cap of more than $3.6 billion. Also on 
March 11th, an insider acquired stock from the company:         Richard C. Wilson
, Board Director, purchased 3,000 shares of the company at an average 
price of $49.42 per share. Following the reported transaction, the 
insider held 8,565 shares of the company, valued at more than $400,000. 
Opposite to the aforementioned companies, wide margins and decent 
returns, coupled with a cheap valuation (12.7 x P/E, compared with the 
39.8 x industry average) make this stock an attractive investment 
option. Furthermore, long-term EPS growth projections that double its 
peers' mean and a 2.57% dividend yield make it a great option for 
patient investors. 
And a U.S. Regional Bank
Finally, we would like to take a look at First Financial Bankshares Inc                 
                    
                        FFIN
                            -0.39%
                    
                
, a $2 billion market cap financial holding firm. Since the beginning of
 the year, the company has seen at least 12 insider purchases take 
place: 
Johnny Trotter
, one of the bank´s Board Directors, has been the most active insider 
this year. Starting on Jan. 31, and through 8 different purchases, Mr. 
Trotter added more than 12,500 shares to his holdings (both direct and 
indirect holdings), having paid prices ranging from $59.40 per share, to
 $62.00 per share. In his most recent transaction, which took place on 
March 14, he procured 7,100 shares of the company for $60.10 each, 
increasing his holdings to more than 195,000 shares of the company, 
valued at than $12 million. 
Another active insider was         Hamilton Murray Edwards
, another Board Director. Between Jan. 29 and Feb. 3rd, he bought more 
than 1,500 shares of the company, for prices between $59.80 per share 
and $62.40 per share. He now owns about 75,000 shares of the firm. 
Despite the insider bullishness and the firm´s above average margins and
 returns, analysts don´t seem to like this stock. In fact, WSJ's 
consensus rating stands at "underweight," with five analysts 
recommending a "hold," and three more advocating for a "sell." With an 
average price target below the current stock price, upside potential 
doesn't look promising. 
 
 
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